Scientists Unveil Itaconate's Role in Fighting Bacteria and Regulating Metabolism
Scientists at the Helmholtz Centre for Infection Research (HZI) and the Technical University of Brunswick have made significant strides in understanding the role of itaconate, a small molecule produced by the body, in regulating metabolism and fighting bacteria. Their research, published recently, sheds light on how this molecule influences enzymes and metabolic pathways, opening up new avenues for treating inflammatory diseases.
The team, led by researchers from both institutions, used advanced techniques such as stable isotope tracing and mass spectrometry to track itaconate's journey in the body. They discovered that itaconate dynamically regulates enzymes and metabolic pathways, complementing previous findings that it temporarily inhibits the enzyme succinate dehydrogenase. The study also revealed that itaconate influences enzymes involved in energy production and amino acid processing by forming itaconyl-Coenzyme A.
In a groundbreaking finding, scientists at the Technical University of Brunswick deciphered how itaconate moves in the body for the first time. They found that a significant portion of itaconate is excreted via the kidneys, while some is converted into central metabolic products and fed into the citric acid cycle. These insights pave the way for further research into developing targeted therapies using itaconate for treating diseases.
The research, published in a leading scientific journal, opens up new approaches for treating inflammatory diseases. While more research is needed to develop targeted therapies, the findings provide a solid foundation for understanding the role of itaconate in metabolism regulation and immune response. The collaborative effort between the HZI and the Technical University of Brunswick highlights the potential of interdisciplinary research in advancing our understanding of complex biological processes.
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