MIT's DEEP Technique Revolutionizes Deep-Tissue Imaging
Researchers at MIT have developed a groundbreaking technique called DEEP, offering high-speed, high-resolution imaging deep into living tissue. The method, detailed in Science Advances, promises to revolutionise deep-tissue imaging.
DEEP, short for De-scattering with Excitation Patterning, is still in its early stages but shows immense potential. The technique uses computational imaging to reverse the scattering process, enabling clear images to be captured 300 microns into the brains of live mice.
Currently, DEEP is faster than other state-of-the-art methods, up to 1,000 times quicker. This speed allows for the imaging of larger tissue volumes and the capture of fast biological processes that were previously inaccessible. Instead of taking months, DEEP can produce high-resolution images in a matter of days.
The team, led by Dushan N. Wadduwage, has demonstrated DEEP's ability to penetrate tissue quickly and widely, producing images comparable to speedtest techniques. This breakthrough addresses the longstanding challenge faced by microscopists: balancing image quality and speed in deep-tissue imaging of living subjects.
DEEP, while still in its early development phase, offers significant advancements in deep-tissue imaging. Its speed and resolution could unlock new insights into biological processes and potentially transform medical imaging. Further development and refinement are expected to enhance its capabilities.
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