Ketogenic Diet Supplement Shows Promise in Angelman Syndrome Trial
A small clinical trial involving children with Angelman syndrome found that a dietary supplement mimicking a ketogenic diet was well-tolerated. The 16-week trial, conducted on 14 children aged 4 to 11, provided the supplement, ketogenic medical food formulation (KF), by Disruptive Nutrition. The trial's primary goal was to assess the supplement's tolerability, which was successfully met with 13 children completing the study and accepting the powder formulation. Two adverse events were reported, one involving elevated triglycerides and another involving low albumin levels, but overall the supplement was deemed safe. Participants experienced softer stool consistency while on KF, a positive effect noted by families. Some even reported reduced food-seeking behavior in their children. Half of the families chose to continue using the formula after the study concluded. Despite these promising signs, the supplement's efficacy could not be determined due to the small number of participants. A larger, longer trial is needed to confirm its safety and potential benefits for Angelman syndrome patients, such as reducing seizures. In summary, a dietary supplement mimicking a ketogenic diet showed promise in a small clinical trial with children with Angelman syndrome. While well-tolerated and showing some potential benefits, further research is needed to confirm its safety and efficacy.
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