Drug Interactions and Linzess: Compatibility with Other Medications, Alcohol, and Substances
Linzess, a brand-name prescription drug, is used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. However, like many medications, it can interact with other drugs and substances, which is why it's essential to be aware of these potential interactions.
One group of drugs that can interact with Linzess are antidiarrheal and anticholinergic drugs. Antidiarrheals can reduce Linzess’s effectiveness because Linzess promotes bowel movements. Anticholinergics, on the other hand, can reduce intestinal motility, potentially counteracting Linzess's pro-secretory effects.
Another type of drug that may interact with Linzess is antacids containing calcium carbonate and magnesium hydroxide, such as Rolaids Ultra Strength. These antacids may alter stomach acidity or gastrointestinal transit time, potentially affecting how Linzess works.
Certain medical conditions and other factors may also increase the risk of interactions with Linzess. Before you take Linzess, it's crucial to discuss your health history with your doctor.
Some specific drugs that can interact with Linzess include bismuth subsalicylate, loperamide, atropine/diphenoxylate, hyoscyamine, oxybutynin, scopolamine, and dicyclomine. If you're taking any of these drugs, it's important to talk with your doctor or pharmacist about potential interactions.
Linzess and lab tests have not been reported to interact with each other. However, for specific information about having certain lab tests during Linzess treatment, it's recommended to talk with your doctor.
It's not known whether Linzess is safe to take during pregnancy or while breastfeeding. If you're pregnant or planning a pregnancy, or if you're breastfeeding or planning to breastfeed, it's important to discuss these matters with your doctor before starting Linzess treatment.
In terms of supplements, Linzess has not been reported to interact with vitamins. However, it's possible that interactions with vitamins could be recognized in the future. This is why you should talk with your doctor or pharmacist before taking any vitamins with Linzess.
Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Linzess. However, as with any drug or supplement, it's always a good idea to talk with your doctor before taking cannabis in combination with Linzess.
It's also worth noting that Linzess should be taken on an empty stomach, at least 30 minutes before your first meal of the day. Taking Linzess with food could increase the risk of diarrhea as a side effect of the drug.
Remember, this article is not exhaustive, and it's always best to consult your doctor or pharmacist for personalised advice. If you have questions about drug interactions that may affect you, it's crucial to ask your doctor or pharmacist.
[References] [1] Drugs.com. (2021). Linzess: Side Effects, Interactions, Warning, Dosage & Uses. Retrieved from https://www.drugs.com/mtm/linzess.html [2] Mayo Clinic. (2021). Linaclotide (Oral route) Side Effects. Retrieved from https://www.mayoclinic.org/drugs-supplements/linaclotide-oral-route/description/drg-20073444 [3] Drugs.com. (2021). Linzess: Drug Interactions. Retrieved from https://www.drugs.com/drug-interactions/linzess.html
- Patients with colitis, ulcerative, or Crohn's disease should be cautious when using Linzess, as its effects on these digestive health conditions are not fully understood.
- Scientists are still exploring the potential predictive role of obesity and its connection with medical-conditions like type 2 diabetes and IBS.
- Medical-conditions such as macular degeneration and hepatitis might affect how the body processes Linzess, potentially resulting in adverse effects.
- AbbVie, the manufacturer of Linzess, advises discussing all health-and-wellness concerns with a healthcare provider before starting treatment.
- The CDI tier for Linzess, a ranking of prescription drug costs, suggests that it may be a more expensive option for some patients.
- Research in the field of science is ongoing to understand the degenerative effects of long-term Linzess use on the intestinal tract.
- Patients with diabetes must be cautious when using Linzess, as it may interact with certain insulin or oral diabetes medications.
- Before starting Linzess treatment, it's vital to disclose any history of drug or supplement interactions, such as atropine/diphenoxylate, hyoscyamine, oxybutynin, scopolamine, and dicyclomine.
- Linzess should not be taken with antidiarrheal or anticholinergic drugs, as their combined effects could neutralize the drug's intended effects on the digestive system.
- Lab tests and vitamins may not directly interact with Linzess, but it's recommended to consult a doctor or pharmacist before taking them concurrently to minimize potential side effects.
