Breakthrough in Brain Disease Treatments: Protein Powers Neurons
Scientists have discovered a key protein that powers brain cells, opening doors to new treatments for neurodegenerative diseases. The study, published in Nature Metabolism, sheds light on Hereditary Spastic Paraplegia 54 (HSP54) and other brain conditions.
The protein, DDHD2, enables neurons to create and use fats for energy. When it malfunctions, as in HSP54, neuron dysfunction occurs. The research team, led by Dr. Merja Joensuu from the Australian Institute for Bioengineering and Nanotechnology, found that supplementing damaged neurons with specific fatty acids restored their energy production and function within 48 hours.
In a separate study, researchers led by Professor Christian Willnow investigated the effects of fatty acids on brain cells in neurodegenerative diseases. Using a custom mouse model with human ApoE variants, they found that ApoE4 negatively impacts nutrient transport and cell membrane receptor function, providing insights for Alzheimer's therapeutic strategies.
These findings could lead to new treatments for previously untreatable brain diseases. The team is now testing fatty acid-based therapies in pre-clinical models before human clinical trials, offering hope for those affected by neurodegenerative conditions like HSP54 and potentially Alzheimer's disease.
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